Advanced protein formulations

Advanced Emulsion Formulations for the Preparation of Encapsulating Systems

Nonconvex piecewise linear functions: Advanced formulations and simple modeling tools

We present novel mixed-integer programming (MIP) formulations for (nonconvex) piecewise linear functions. Leveraging recent advances in the systematic construction of MIP formulations for disjunctive sets, we derive new formulations for univariate functions using a geometric approach, and for bivariate functions using a combinatorial approach. All formulations derived are small (logarithmic in ...

Therapeutic angiogenesis in cardiology using protein formulations.

Therapeutic angiogenesis in cardiovascular disease aims at improving myocardial function by increasing blood flow to ischemic myocardium that is not amenable to traditional forms of revascularization. Preclinical data have provided proof of the concept that angiogenic growth factors such as fibroblast growth factor 2 (FGF-2) and vascular endothelium growth factor (VEGF) may indeed improve myoca...

Methods of Measuring the Tg of Lyophilized Protein-Excipient Formulations

mixtures strives to develop a product with good shelf life and that allows efficient dissolution by the end user with minimal change to the properties of the drug. One of the key properties used in the design of the formulations is the glass transition temperature, Tg, which must be sufficiently above the storage temperature to limit any degradation properties from occurring at significant rate...

Rational design of stable lyophilized protein formulations: theory and practice.